Endocrine Abstracts

Introduction: Decidualisation of the endometrial stromal cell (ESC) is pivotal for successful implantation and is initiated in response to increasing progesterone levels. Transforming Growth Factor-β1 (TGFβ-1), a potent cytokine involved in many diverse cellular responses, is activated from the latent form in the mid-late secretory phase. Previous reports suggest that TGFβ-1 might oppose the action of progesterone, although no mechanism has been proposed. We hav...